Publications

Ioana Olan*, Masami Ando-Kuri*, Aled J. Parry*, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser, Yasuyuki Ohkawa, Hiroshi Kimura, Masako Narita & Masashi Narita. HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity. Nat Commun 15, 6891 (2024). https://doi.org/10.1038/s41467-024-51153-8 

Adelyne S. L. Chan*, Haoran Zhu*, Masako Narita, Liam D. Cassidy, Andrew R. J. Young, Camino Bermejo-Rodriguez, Aleksandra T. Janowska, Hung-Chang Chen, Sarah Gough, Naoki Oshimori, Lars Zender, Sarah J. Aitken, Matthew Hoare & Masashi Narita. Titration of RAS alters senescent state and influences tumour initiation. Nature (2024). doi.org/10.1038/s41586-024-07797-z

Camino Bermejo-Rodriguez, Joaquín Araos Henríquez§, Giuseppina Caligiuri§, Sara Pinto Teles, Youngkyu Park, Anthony Evans, Lawrence N. Barrera, Albrecht Neesse, Robert Grutzmann, Daniela Aust, Petra Rümmele, Thomas Knösel, Masako Narita, Masashi Narita, Fiona Campbell, Daniel Öhlund, Christian Pilarsky, Lukas E. Dow, Patrick O. Humbert, Giulia Biffi, David A. Tuveson, Pedro A. Perez-Mancera. Cancer Research (2024). doi.org/10.1158/0008-5472.CAN-23-3419

Tomimatsu K, Fujii T, Bise R, Hosoda K, Taniguchi Y, Ochiai H, Ohishi H, Ando K, Minami R, Tanaka K, Tachibana T, Mori S, Harada A, Maehara K, Nagasaki M, Uchida S, Kimura H, Narita M, Ohkawa Y (2024). Precise immunofluorescence canceling for highly multiplexed imaging to capture specific cell states. Nat Commun, 15(1):3657. doi.org/10.1038/s41467-024-47989-9

Patra M, Klochendler A, Condiotti R, Kaffe B, Elgavish S, Drawshy Z, Avrahami D, Narita M, Hofree M, Drier Y, Meshorer E, Dor Y, Ben-Porath I (2024). Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness. Nucleic Acids Res., gkae313. doi.org/10.1093/nar/gkae313

Masako Narita, Ioana Olan, Masashi Narita (2024). Determining the Compaction State of Genes Using DNA FISH. Methods Mol Biol 2784:215-225. doi.org/10.1007/978-1-0716-3766-1_15

Ioana Olan, Masami Ando Kuri, Aled Parry, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser, Yasuyuki Ohkawa, Hiroshi Kimura, Masako Narita & Masashi Narita (2024). HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D1 networks coordinating senescence heterogeneity. Research Square (Preprint): doi.org/10.21203/rs.3.rs-3621476/v1

Charlotte Collins, Simon Baker, Jason Brown, Huiyuan Zheng, Adelyne Chan, Ulla Stenius, Masashi Narita and Anna Korhonen (2024). Text Mining for Contexts and Relationships in Cancer Genomics Literature. Bioinformatics, btae021 https://doi.org/10.1093/bioinformatics/btae021

Adil Jaulim, Liam Cassidy, Andrew Young, Adelyne Chan, Anne Warren, Angela Taylor, Wiebke Arlt, Guochen Lan, Martyn Blayney, Olivia Davidson, Christopher Barratt, Simon Pacey, Masashi Narita (2023). Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility. bioRxiv (Preprint): https://doi.org/10.1101/2023.07.21.549845

Ioana Olan, Tetsuya Handa, Masashi Narita (2023). Beyond SAHF: An integrative view of chromatin compartmentalization during senescence. Current Opinion in Cell Biology 83, 102206: doi.org/10.1016/j.ceb.2023.102206

Adelyne Chan, Haoran Zhu, Masako Narita, Liam Cassidy, Andrew Young, Camino Bermejo-Rodriguez, Aleksandra Janowska,  Naoki Oshimori,  Lars Zender, Sarah Aitken, Matthew Hoare, Masashi Narita (2023). Titration of oncogenic RAS alters senescent state and influences tumour initiation. Research Square (Preprint): doi.org/10.21203/rs.3.rs-2842963/v1

Darren J. Baker, Masashi Narita and Pura Munoz-Canoves (2023). Cellular senescence: beneficial, harmful, and highly complex. FEBS 290, 1156–1160. DOI: doi:10.1111/febs.16735

Yangteng Ou, Shixiang Cao, Yang Zhang, Hongjia Zhu, Chengzhi Guo, Wei Yan, Fengxue Xin, Weiliang Dong, Yanli Zhang, Masashi Narita, Ziyi Yu & Tuomas P. J. Knowles (2023). Bioprinting microporous functional living materials from protein-based core-shell microgels. Nature Communications 14, 322. DOI: doi.org/10.1038/s41467-022-35140-5

Zhu H, Roode LWY, Parry AJ, Erkamp NA, Rodriguez-Garcia M, Narita M, Shen Y, Ou Y, Toprakcioglu Z, Narita M & Knowles TPJ (2022). Core-shell spheroid-laden microgels crosslinked under biocompatible conditions for probing cancer-stromal communication. Adv Biomed Res. 2, 2200138. DOI: 10.1002/anbr.202200138

Hongjia Zhu, Masako Narita, Jerelle A Joseph, Georg Krainer, William E Arter, Ioana Olan, Kadi L Saar, Niklas Ermann, Jorge R Espinosa, Yi Shen, Runzhang Qi, Masami Ando Kuri, Timothy Welsh, Rosana Collepardo-Guevara, Masashi Narita, Tuomas Pertti Jonathan Knowles (2022). The chromatin regulator HMGA1a undergoes phase separation in the nucleus. Chembiochem.  e202200450. DOI: 10.1002/cbic.202200450.

Khoosheh Khayati, Vrushank Bhatt, Taijin Lan, Fawzi Alogaili, Wenping Wang, Enrique Lopez, Zhixian Sherrie Hu, Samantha Gokhale, Liam Cassidy, Masashi Narita, Ping Xie, Eileen White & Jessie Yanxiang Guo (2022). Transient Systemic Autophagy Inhibition is Selectively and Irreversibly Deleterious to Lung Cancer. Cancer Research. 82(23): 4429–4443. DOI: doi.org/10.1158/0008-5472.CAN-22-1039.

Ioana Olan & Masashi Narita (2022). Senescence: An Identity Crisis Originating from Deep Within the Nucleus. Annual Review of Cell and Developmental Biology. 38:219-239. DOI: doi.org/10.1146/annurev-cellbio-120420-013537.

Liam Cassidy & Masashi Narita (2022). Autophagy at the intersection of aging, senescence, and cancer. Mol Oncol. 16(18):3259-3275. DOI: 10.1002/1878-0261.13269. PMID: 35689420.

Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan, Liam Cassidy, Marta Poblocka, Haoran Zhu, Aaron Lun, Martijn Schuijs, Andrew Young, Celia Martinez-Jimenez, Timotheus Y F Halim, Shishir Shetty, Masashi Narita & Matthew Hoare (2022). Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance. Genes & Dev. 36(9-10):533-549. DOI: 10.1101/gad.349585.122. PMID: 35618311.

Adelyne Chan & Masashi Narita (2022). A role for CUX1 in the regulation of p16 and senescence. Nature Aging. 2, 100–101 DOI: 10.1038/s43587-022-00173-4. 

Kosuke Tomimatsu, Dóra Bihary, Ioana Olan, Aled J. Parry, Stefan Schoenfelder, Adelyne S. L. Chan, Guy St. C. Slater, Yoko Ito, Peter J. Rugg-Gunn, Kristina Kirschner, Camino Bermejo-Rodriguez, Tomomi Seko, Hiroyuki Kugoh, Ken Shiraishi, Koji Sayama, Hiroshi Kimura, Peter Fraser, Masako Narita, Shamith A. Samarajiwa & Masashi Narita (2022). Locus-specific induction of gene expression from heterochromatin loci during cellular senescence. Nature Aging 2, 31–45. DOI: 10.1038/s43587-021-00147-y.

Hongjia Zhu, Masako Narita, Jerelle Joseph, Georg Krainer, William Arter, Ioana Olan, Kadi Saar, Niklas Ermann, Jorge Espinosa, Yi Shen, Masami Ando Kuri, Runzhang Qi, Timothy Welsh, Yufan Xu, Rosana Collepardo-Guevara, Masashi Narita, Tuomas P. J. Knowles (2022). The chromatin regulator HMGA1a undergoes phase separation in the nucleus. DOI: doi.org/10.1101/2021.10.14.464384. Preprint ahead of publication.

Eleanor Sheekey, Masashi Narita (2021). p53 in senescence – it's a marathon not a sprint. FEBS J. Online ahead of print. DOI: 10.1111/febs.16325

Ioana Olan & Masashi Narita (2021). Putting the DOT on IL1A. J Cell Biol. 220 (8): e202106164. DOI: doi.org/10.1083/jcb.202106164. PMID: 34254986.

Susana Gonçalves, Kelvin Yin, Yoko Ito, Adelyne Chan, Ioana Olan, Sarah Gough, Liam Cassidy, Eva Serrao, Stephen Smith, Andrew Young, Masashi Narita & Matthew Hoare (2021). COX2 regulates senescence secretome composition and senescence surveillance through PGE2. Cell Reports 34(11), 108860. DOI: doi.org/10.1016/j.celrep.2021.108860. PMID: 33730589.

Rafael Alcalá-Vida, Marta Garcia-Forn, Carla Castany-Pladevall, Jordi Creus-Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí-Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez-Navarro (2021). Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease. EMBO Mol Med 13:e12105. DOI: doi.org/10.15252/emmm.202012105. PMID: 33369245.

Ioana Olan, Aled Parry, Stefan Schoenfelder, Masako Narita, Yoko Ito, Adelyne Chan, Guy Slater, Dóra Bihary, Masashige Bando, Katsuhiko Shirahige, Hiroshi Kimura, Shamith Samarajiwa, Peter Fraser & Masashi Narita (2020). Nature Communications 11(1): 6049. DOI: doi.org/10.1038/s41467-020-19878-4. PMID: 33247104.

Mélanie Eckersley-Maslin, Aled Parry, Marloes Blotenburg, Christel Krueger, Yoko Ito, Valar Nila Roamio Franklin, Masashi Narita, Clive D’Santos & Wolf Reik (2020). Epigenetic priming by Dppa2 and 4 in pluripotency facilitates multi-lineage commitment. Nature Structural & Molecular Biology. 27(8):696-705. DOI: doi.org/10.1038/s41594-020-0443-3. PMID: 32572255.

Liam Cassidy & Masashi Narita (2020). Dynamic modulation of autophagy: implications for aging and cancer.  Mol Cell Oncol. 7(4):1754723. DOI: doi.org/10.1080/23723556.2020.1754723. PMID: 32944616.

Liam Cassidy, Andrew Young, Christopher Young, Elizabeth Soilleux, Edward Fielder, Bettina Weigand, Anthony Lagnado, Rebecca Brais, Nicholas Ktistakis, Kimberley Wiggins, Katerina Pyrillou, Murray Clarke, Diana Jurk, Joao Passos & Masashi Narita (2020). Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk. Nature Communications 11(1):307. DOI: 10.1038/s41467-019-14187-x. PMID: 31949142.

Kimberley Wiggins, Aled Parry, Liam Cassidy, Melanie Humphry, Steve Webster, Jane Goodall, Masashi Narita, Murray Clarke (2019). IL-1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence-associated secretory phenotype. Aging Cell. 18(3):e12946. DOI: 10.1111/acel.12946. PMID: 30916891.

Masashi Narita (2019). Crisis management by autophagy. Nature Structural & Molecular Biology 26, 151–152. DOI: 10.1038/s41594-019-0195-0. PMID: 30705353.

Sampo Pyysalo, Simon Baker, Imran Ali, Stefan Haselwimmer, Tejas Shah, Andrew Young, Yufan Guo, Johan Högberg, Ulla Stenius, Masashi Narita, Anna Korhonen (2019). LION LBD: a literature-based discovery system for cancer biology. Bioinformatics. 35(9):1553-1561. DOI: 10.1093/bioinformatics/bty845. PMID: 30304355. (Webtool: http://lbd.lionproject.net/).

Liam Cassidy, Andrew Young , Pedro Pérez-Mancera, Birgit Nimmervoll, Adil Jaulim, Hung-Chang Chen, Dominick McIntyre, Rebecca Brais, Thomas Ricketts, Simon Pacey, Maike De La Roche, Richard Gilbertson, David Rubinsztein & Masashi Narita (2018). A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo. Autophagy. 14(7):1256-1266. DOI: 10.1080/15548627.2018.1458172. PMID: 29999454.

Aled Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa & Masashi Narita (2018). NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence. Nature Communications 9(1):1840. DOI: 10.1038/s41467-018-04283-9. PMID: 29743479.

Matthew Hoare and Masashi Narita (2018). The Power Behind the Throne: Senescence and the Hallmarks of Cancer. Annual Review of Cancer Biology. 2:175-194 DOI: 10.1146/annurev-cancerbio-030617-050352. 

Yoko Ito, Matthew Hoare, Masashi Narita (2017). Spatial and Temporal Control of Senescence. Trends Cell Biol. 27(11):820-832. DOI: 10.1016/j.tcb.2017.07.004. PMID: 28822679.

Claire Cairney, Lauren Godwin, Alan Bilsland, Sharon Burns, Katrina Stevenson, Lynn McGarry, John Revie, Jon Moore, Ceri Wiggins, Rebecca Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy Bennett, Masashi Narita, Christopher Torrance, W. Nicol Keith (2017). A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet. 13(8):e1006942. DOI: 10.1371/journal.pgen.1006942. PMID: 28806777.

Masako Narita & Masashi Narita (2017). Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy. Methods Mol Biol. 1534, 89-98. DOI: 10.1007/978-1-4939-6670-7_8. PMID: 27812870.

Kosuke Tomimatsu, Kenji Kokura, Tadashi Nishida, Yuki Yoshimura, Yasuhiro Kazuki, Masashi Narita, Mitsuo Oshimura, Tetsuya Ohbayashi (2017). Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome. FEBS Open Bio. 7(3):306-317. DOI: 10.1002/2211-5463.12169. PMID: 28286726.

Matthew Hoare & Masashi Narita (2016). NOTCH and the 2 SASPs of senescence. Cell Cycle. 20:1-2. DOI: 10.1080/15384101.2016.1248730. PMID: 27764549.

Robert Hänsel-Hertsch, Dario Beraldi, Stefanie Lensing, Giovanni Marsico, Katherine Zyner, Aled Parry, Marco Di Antonio, Jeremy Pike, Hiroshi Kimura, Masashi Narita, David Tannahill & Shankar Balasubramanian (2016). G-quadruplex structures mark human regulatory chromatin. Nat Genet. 48(10):1267-72. DOI: 10.1038/ng.3662.  PMID: 27618450.

Matthew Hoare, Yoko Ito, Tae-Won Kang, Michael Weekes, Nicholas Matheson, Daniel Patten, Shishir Shetty, Aled Parry, Suraj Menon, Rafik Salama, Robin Antrobus, Kosuke Tomimatsu, William Howat, Paul Lehner, Lars Zender & Masashi Narita (2016). NOTCH1 mediates a switch between two distinct secretomes during senescence. Nat Cell Biol. 18(9):979-92. DOI: 10.1038/ncb3397. PMID: 27525720.

Kenneth Durbin, Luca Fornelli, Ryan Fellers, Peter Doubleday, Masashi Narita, Neil Kelleher (2016). Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa. J Proteome Res. 15(3):976-82. DOI: 10.1021/acs.jproteome.5b00997. PMID: 26795204.

Niehues H, van Vlijmen-Willems IM, Bergboer JG, Kersten FF, Narita M, Hendriks WJ, van den Bogaard EH, Zeeuwen PL, Schalkwijk J. (2016). Late cornified envelope (LCE) proteins: Distinct expression patterns of LCE2 and LCE3 members suggest non-redundant roles in human epidermis and other epithelia. Br J Dermatol. 174(4):795-802. DOI: 10.1111/bjd.14284. PMID: 26556599.

Alan E Bilsland, Angelo Pugliese, Yu Liu, John Revie, Sharon Burns, Carol McCormick, Claire Cairney, Justin Bower, Martin Drysdale, Masashi Narita, Mahito Sadaie, W Nicol Keith (2015). Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia 17(9):704-15. DOI: 10.1016/j.neo.2015.08.009. PMID: 26476078.

Basetti Madhu, Masako Narita, Alexandra Jauhiainen, Suraj Menon, Marion Stubbs, Simon Tavaré, Masashi Narita, John R Griffiths (2015). Metabolomic changes during cellular transformation monitored by metabolite–metabolite correlation analysis and correlated with gene expression. Metabolomics. 11(6):1848-1863. DOI: 10.1007/s11306-015-0838-z. PMID: 26491426.

Mahito Sadaie, Christian Dillon, Masako Narita, Andrew Young, Claire Cairney, Lauren Godwin, Christopher Torrance, Dorothy Bennett, W Nicol Keith, Masashi Narita (2015). Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26(17):2971-85. DOI: 10.1091/mbc.E15-01-0003. PMID: 26133385.

Kristina Kirschner, Shamith Samarajiwa,  Jonathan Cairns, Suraj Menon, Pedro Pérez-Mancera , Kosuke Tomimatsu, Camino Bermejo-Rodriguez, Yoko Ito, Tamir Chandra, Masako Narita, Scott Lyons, Andy Lynch, Hiroshi Kimura, Tetsuya Ohbayashi, Simon Tavaré, Masashi Narita (2015). Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLOS Genetics 11(3) p. e1005053. DOI: 10.1371/journal.pgen.1005053. PMID: 25790137.

Luis Duarte, Andrew Young, Zichen Wang, Hsan-Au Wu, Taniya Panda, Yan Kou, Avnish Kapoor, Dan Hasson, Nicholas R. Mills, Avi Ma’ayan, Masashi Narita & Emily Bernstein (2014). Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Nat Commun. 5:5210. DOI: 10.1038/ncomms6210.  PMID: 25394905.

Alexandra Jauhiainen, Basetti Madhu, Masako Narita, Masashi Narita, John Griffiths, Simon Tavaré (2014). Normalization of metabolomics data with applications to correlation maps. Bioinformatics. 30: 2155-61. DOI: 10.1093/bioinformatics/btu175. PMID: 24711654.

Mahito Sadaie, Rafik Salama, Thomas Carroll, Kosuke Tomimatsu, Tamir Chandra, Andrew Young, Masako Narita, Pedro Pérez-Mancera, Dorothy Bennett, Heung Chong, Hiroshi Kimura, Masashi Narita (2013). Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev. 27: 1800-1808. DOI: 10.1101/gad.217281.113. PMID: 23964094.

Tamir Chandra, Kristina Kirschner, Jean-Yves Thuret, Benjamin D Pope, Tyrone Ryba, Scott Newman, Kashif Ahmed, Shamith A Samarajiwa, Rafik Salama, Thomas Carroll, Rory Stark, Rekin's Janky, Masako Narita, Lixiang Xue, Agustin Chicas, Sabrina Nũnez, Ralf Janknecht, Yoko Hayashi-Takanaka, Michael D Wilson, Aileen Marshall, Duncan T Odom, M Madan Babu, David P Bazett-Jones, Simon Tavaré, Paul A W Edwards, Scott W Lowe, Hiroshi Kimura, David M Gilbert, Masashi Narita (2012). Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation. Mol Cell 47: 203-14. DOI: 10.1016/j.molcel.2012.06.010. PMID: 22795131.

Akiyuki Hirosue, Ko Ishihara, Kazuaki Tokunaga, Takehisa Watanabe, Noriko Saitoh, Masafumi Nakamoto, Tamir Chandra, Masashi Narita, Masanori Shinohara, Mitsuyoshi Nakao (2012). Quantitative assessment of higher-order chromatin structure of the INK4/ARF locus in human senescent cells. Aging Cell, 11: 553-6. DOI: 10.1111/j.1474-9726.2012.00809.x. PMID: 22340434.

Masako Narita*, Andrew Young*, Satoko Arakawa, Shamith A Samarajiwa, Takayuki Nakashima, Sei Yoshida, Sungki Hong, Lorraine S Berry, Stefanie Reichelt, Manuela Ferreira, Simon Tavaré, Ken Inoki, Shigeomi Shimizu & Masashi Narita (2011). Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes. Science, 332: 966-70. DOI: 10.1126/science.1205407. PMID: 21512002.

Andrew Young*, Masako Narita*, Manuela Ferreira, Kristina Kirschner, Mahito Sadaie, Jeremy Darot, Simon Tavaré, Satoko Arakawa, Shigeomi Shimizu, Fiona Watt, Masashi Narita (2009). Autophagy mediates the mitotic-senescence transition. Genes Dev. 23: 798-803. DOI: 10.1101/gad.519709. PMID: 19279323.